منابع مشابه
Proteolysis: Adaptor, Adaptor, Catch Me a Catch
The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.
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What has been your biggest error? Back at the beginning of this century, I used to say “I am going to spend the rest of my life trapped in a mitochondrion!”. This was because I was convinced that it was never going to be possible to retrieve even partial extinct genomes. Now, there are genomic sequences for many ancient humans and animals. This goes back to the famous Arthur C. Clarke quote: “W...
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A recent study shows that the leukocyte adhesion molecules known as selectins form 'catch' bonds, the dissociation rate of which decreases with increasing applied force. The ability of selectins to switch between catch and slip bonds, where dissociation increases with force, can explain the shear threshold effect, in which leukocyte adhesion goes through a maximum with increasing shear rate.
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One strategy for estimating total catch is to employ two separate surveys that independently estimate total fishing effort and catch rate with the estimator for total catch formed by their product. Survey designs for estimating catch rate often involve interviewing the fishermen during their fishing episodes. Such roving designs result in incomplete episode data and characteristically have empl...
متن کاملStatistics catch-up lecture
Example 1. In a genetic study, n = 2217 patients are recruited, among which 1127 have bladder cancer. After whole genome sequencing, p = 475290 single nucleatide polymorphisms (or SNPs, a possible variation of the DNA sequence at one location) are measured on each patient. We construct a matrix X = (Xij)1≤i≤n,1≤j≤p where Xij = 1 if the ith patient has a mutation at jth location and 0 otherwise....
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.circulationaha.104.514265